1. Fundamental understanding
2. Predictive ability
Several design quality measures can help you judge how well a design can help you achieve these goals -- before you collect any data!

First let's look at quality measures that help us judge the ability of an experiment design to extract information about effects -- fundamental understanding.
VIFs: VIFs are Variance Inflation Factors. They tell you how "clean" the estimate of an effect is. A VIF of 1 indicates that the effect is free from any contamination from other effects. A design with all VIFs equal to 1 is ideal. VIFs larger than 1 indicate some level of contamination from other effects. VIFs larger than 5 generally indicate such a high level of contamination that the design will not separate effects well enough to learn anything about them. The model may still predict well -- you just won't be able to rank the effects.
Correlation Matrix: The correlation matrix also measures how "clean" effect estimates will be. The correlation matrix is more detailed in identifying the source of the contamination. A perfect correlation matrix has all ones on the main diagonal and zeroes everywhere else. This means each effect is correlated perfectly with itself and not at all correlated with anything else. Any off diagonal elements that are not zero indicate some level of correlation between 2 effects -- contamination. Most experts advise keeping off diagonal elements between -0.95 and 0.95. Once again, a design with a poor correlation matrix may allow you to fit a model that predicts well, but you won't be able to rank the effects.
Relative Variance of Coefficients: The power for identifying various coefficients should as high as possible to rank the effects accurately. Try to keep the power over 0.8. As before, a model built from a design with low power for the relative variance of the coefficients could still predict well.
Next time let's look at design quality measures that tell us about predictive ability.




